Neuraxial block, death and serious cardiovascular morbidity in the POISE trial†

K. Leslie1,2*, P. Myles4,5,7, P. Devereaux8,9,10, E. Williamson3,6, P. Rao-Melancini11, A. Forbes6, S. Xu12, P. Foex13, J. Pogue11, M. Arrieta14,15, G. Bryson16, J. Paul17, M. Paech18,19, R. Merchant20, P. Choi21,22, N. Badner23, P. Peyton24,25, J. Sear13 and H. Yang26 1 Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia 2 Department of Pharmacology and 3 School of Population Health, University of Melbourne, Melbourne, Australia 4 Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Australia 5 Academic Board of Anaesthesia and Perioperative Medicine and 6 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia 7 National Health and Medical Research Council Practitioner Fellow, Canberra, Australia 8 Department of Medicine, 9 Department of Clinical Epidemiology and 10 Department of Biostatistics, McMaster University, Hamilton, Canada 11 Population Health Research Institute, McMaster University, Hamilton, Canada 12 Fu Wai Cardiovascular Hospital, CAMS, Beijing, People’s Republic of China 13 Nuffield Department of Anaesthetics, Oxford University, Oxford, UK 14 Nueva Granada Military University, Bogota, Colombia 15 Department of Anaesthesia, Resuscitation and Pain Management, Central Military Hospital, Bogota, Colombia 16 Department of Anesthesiology, The Ottawa Hospital, Ottawa, Canada 17 Department of Anaesthesia, McMaster University, Hamilton Health Sciences, Hamilton, Canada 18 School of Medicine and Pharmacology, University of Western Australia, Perth, Australia 19 Department of Anaesthesia and Pain Medicine, King Edward Memorial Hospital for Women, Perth, Australia 20 Department of Anaesthesia and Perioperative Medicine, Royal Columbian Hospital, New Westminster, Canada 21 Department of Anesthesiology, Pharmacology and Therapeutics, 22 School of Population and Public Health, The University of British Columbia, Vancouver, Canada 23 Department of Anaesthesia and Perioperative Medicine, The University of British Columbia, Kelowna, Canada 24 Department of Anaesthesia, Austin Hospital, Melbourne, Australia 25 Department of Surgery, Austin Hospital and University of Melbourne, Melbourne, Australia 26 Department of Anaesthesia, University of Ottawa, Ottawa, Canada